Our Research

In addition to our care activity,
we are attached to research
and innovation in rhythmology.
This explains our desire to keep
a university and academic activity.
We participate in many congresses
and train young doctors to
rhythmology.

Our Publications

Reproducibility of acute pulmonary vein isolation guided by the ablation index. Solimene F, Lepillier A, De Ruvo E, Scaglione M, Anselmino M, Sebag FA, Pecora D, Gallagher MM, Rillo M, Viola G, Rossi L, De Santis V, Landolina M, Castro A, Grimaldi M, Badenco N, Del Greco M, De Simone A, Bertaglia E, Stabile G. Pacing Clin Electrophysiol. 2019.

Progression of excitation-contraction coupling defects in doxorubicin cardiotoxicity. Llach A, Mazevet M, Mateo P, Villejoubert O, Ridoux A, Rucker-Martin C, Ribeiro M, Fischmeister R, Crozatier B, Benitah JP, Morel E, Gómez AM. J Mol Cell Cardiol. 2019.

Cost-effectiveness of a risk-stratified approach to cardiac resynchronisation therapy defibrillators (high versus low) at the time of generator change. Claridge S, Sebag FA, Fearn S, Behar JM, Porter B, Jackson T, et al. Heart. 2017.

Early Anterior Mitral Valve Leaflet Mechanical Erosion Following Left Atrial Appendage Occluder Implantation. Berrebi A, Sebag FA, Diakov C, Amabile N. JACC Cardiovasc Interv. 2017.

RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism. Wang YY, Mesirca P, Marqués-Sulé E, Zahradnikova A Jr, Villejoubert O, D’Ocon P, Ruiz C, Domingo D, Zorio E, Mangoni ME, Benitah JP, Gómez AM. JCI Insight. 2017.

Causes of Death and Influencing Factors in Patients with Atrial Fibrillation. Fauchier L, Villejoubert O, Clementy N, Bernard A, Pierre B, Angoulvant D, Ivanes F, Babuty D, Lip GY. Am J Med. 2016.

Atrial flutter in myotonic dystrophy type 1: Patient characteristics and clinical outcome. Wahbi K, Sebag FA, Lellouche N, Lazarus A, Bécane H-M, Bassez G, et al. Neuromuscul Disord. 2016.

Effect of Active Smoking on Comparative Efficacy of Antithrombotic Therapy in Patients With Atrial Fibrillation: The Loire Valley Atrial Fibrillation Project. Angoulvant D, Villejoubert O, Bejan-Angoulvant T, Ivanes F, Saint Etienne C, Lip GYH, Fauchier L. Chest. 2015.

Vasovagal syncope and multidisciplinary rehabilitation : a prospective randomized study. Siméon E, Bernard-Brunet A, Clémenty N, El Hage W, Monpère C, Babuty D. Int J Cardiol. 2015.

History of thyroid disorders in relation clinical outcomes in atrial fibrillation. Bruere H, Fauchier L, Simeon E, Babuty D, Clémenty N.Am J Med 2015.

Positive response to cardiac resynchronization therapy reduces arrhythmic events after elective generator change in patients with primary prevention CRT-D. Sebag FA, Lellouche N, Chen Z, Tritar A, O’Neill MD, Gill J, et al. J Cardiovasc Electrophysiol. 2014.

Insufficiency of electrocardiogram alone in predicting infrahissian abnormalities in patients with type 1 myotonic dystrophy. Siméon E, Patier-Dussauge A, Bernard-Brunet A, Clémenty N, Gouraud JB, Guyaumarch B, Probst V, Babuty D. Int J Cardiol 2014.

Cardiac device implantation in Fabry disease: A retrospective monocentric study. Sené T, Lidove O, Sebbah J, Darondel JM, Picard H, Aaron L, Fain O, Zenone T, Joly D, Charron P, Ziza JM. Medicine (Baltimore). 2016.

Prevalence and clinical impact of QRS duration in patients with low-flow/low-gradient aortic stenosis due to left ventricular systolic dysfunction. Sebag FA, Lellouche N, Chaachoui N, Dubois-Rande J-L, Gueret P, Monin J-L. Eur J Heart Fail. 2014.

Outcomes after ablation for typical atrial flutter (from the Loire Valley Atrial Fibrillation Project). Clémenty N, Desprets L, Pierre B, Simeon E, Babuty D, Fauchier L. Am J Cardiol. 2014.

Programming implantable cardioverter-defibrillators in primary prevention: higher or later. Clémenty N, Pierre B, Siméon E, Lallemand B, Fauchier L, Babuty D. Arch Cardiovasc Dis 2014.

Efficacy of new anticoagulants in patients with atrial fibrillation previously treated with warfarin: a meta-analysis of randomized control trials. Fauchier L, Clémenty N, Saint Etienne C, Siméon E, Angoulvant D, Bernard-Brunet A. Int J Cardiol 2014.

Prognosis in patients hospitalized with permanent and nonpermanent atrial fibrillation in heart failure. Taillandier S, Brunet-Bernard A, Lallemand B, Siméon E, Péricart L, Clémenty N, Babuty D, Fauchier L. Am J Cardiol 2014.

Quantitative assessment of the effects of therapeutic hypothermia on early repolarization in idiopathic ventricular fibrillation survivors: a 7-year cohort study. Williams SE, Sabir I, Nimmo C, Linton N, Sebag FA, Harrison JL, et al. Circ Arrhythm Electrophysiol. 2014.

The prevalence of electrocardiographic early repolarization in an adult cohort with chronic kidney disease and its impact upon all-cause mortality and progression to dialysis. Hajhosseiny R, Rajani R, Khavandi K, Sebag FA, Mashayekhi S, Wright M, et al. Front Physiol. 2013.

Antiplatelet therapy strategies after percutaneous coronary intervention in patients needing oral anticoagulation. Etienne CS, Angoulvant D, Siméon E and Fauchier L. Future Cardiol 2013.
Persistent atrial fibrillation presenting in sinus rhythm: pulmonary vein isolation versus pulmonary vein isolation plus electrogram-guided ablation. Sebag FA, Chaachoui N, Linton NW, Amraoui S, Harrison J, Williams S, et al. Arch Cardiovasc Dis. 2013.

Pronostic value of programmed ventricular stimulation in Brugada syndrome according to clinical présentation : an updated meta-analysis of worldwide published data. Fauchier L, Isorni MA, Clémenty N, Pierre B, Siméon E, Babuty D. Int J Cardiol 2013.
Reverse electrical remodeling by cardiac resynchronization therapy: prevalence and clinical impact. Sebag FA, Martins RP, Defaye P, Hidden-Lucet F, Mabo P, Daubert J-C, et al. J Cardiovasc Electrophysiol. 2012.

Perte de connaissance : trucs et astuces pour authentifier une étiologie cardiaque. Babuty D, Bernard-Brunet A et Siméon E. Cardiologie pratique 2012.

Transfemoral implantation of an Edwards SAPIEN valve in a tricuspid bioprosthesis without fluoroscopic landmarks. Calvert PA, Himbert D, Brochet E, Radu C, Iung B, Hvass U, Darondel JM, Depoix JP, Nataf P, Vahanian A. EuroIntervention. 2012.

Acute pericardial effusion following atrial fibrillation ablation: characteristics and relationship with arrhythmia recurrences. Lellouche N, Sebag FA, Elbaz N, Hassine M, Chaachoui N, Teiger E, et al. Arch Cardiovasc Dis. 2011.

Sudden cardiac arrest: ECG repolarization after resuscitation. Sacher F, Jorrot P, Cariou A, Spaulding C, Aurore A, Combes X, Fichet J, Teiger E, Jais P, Dubois-Randé JL, Haissaguerre M. J Cardiovasc Electrophysiol. 2011.

New energy sources for ablative methods. Lavergne T, Ollitrault J, Sebag C, Le Heuzey JY, Paziaud O, Aït Saïd M, Cauchemez B, Darondel JM, Guize L. Arch Mal Coeur Vaiss. 2005.

Basal asynchrony and resynchronization with biventricular pacing predict long-term improvement of LV function in heart failure patients. Toussaint JF, Lavergne T, Kerrou K, Froissart M, Ollitrault J, Darondel JM, Alonso C, Diebold B, Le Heuzey JY, Guize L, Paillard M. Pacing Clin Electrophysiol. 2003.

Predictive value of acute echocardiographic changes for long term efficacy of biventricular pacing. Darondel JM, Lavergne T, Toussaint JF, PhD, Ait Said M, Passet L, Ollitrault J, Leheuzey JY, Guize L. Circulation Abstract AHA Nov 2002.

Arrhythmic cardiomyopathy. Lavergne T, Sebag C, Ollitrault H, Le Heuzey JY, Darondel JM, Piot O, Guize L. Arch Mal Coeur Vaiss. 2001.

Biventricular pacing in severe heart failure patients reverses electromechanical dyssynchronization from apex to base. Toussaint JF, Lavergne T, Ollitraut J, Hignette C, Darondel JM, De Dieuleveult B, Froissart M, Le Heuzey JY, Guize L, Paillard M. Pacing Clin Electrophysiol. 2000.

Validation of the measurement of cardiac output by acoustic quantification in patients with severe congestive heart failure. Vermes E, Leroy G, Soustelle C, Otmani A, Darondel JM, Halphen C, Haiat R. Arch Mal Coeur Vaiss. 2000.

Acute pulmonary edema following amphetamine ingestion. Maury E, Darondel JM, Buisinne A, Guitton C, Offenstadt G. Intensive Care Med. 1999.

AF ESUS study

The main objective of the AF-ESUS study is to compare the prevalence of occult atrial fibrillation detected by an implantable ECG monitor in the course of a cerebral infarction meeting the criteria of ESUS according to Hart, without a source of cardiac embolism (ECG ) major in transesophageal ultrasound and without atrial fibrillation on a 72h Holter ECG placed on admission, between two subgroups: a first subgroup of patients with indirect or potential SCE in OTE and a second subgroup called ” ESUS true ”, without SCE in ETO.

WEAR IT study

This is an observational, multicenter study of routine care. post-marketing, requested by the Haute Autorité de Santé for the re-registration of LifeVest (r) on the list of reimbursable products.

Our Research

Our Publications

AF ESUS study

WEAR IT study

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